This is not the original artwork but the book itself. However, this early comic book was the first ever created with art done specifically for it.
Buster Brown's Experiences with Pond's Extract (1904) is the first ever premium comic book to have art done specifically for the piece. Fabulous work by Richard Outcault (creator of the first comic character the Yellow Kid) is twenty-eight pages in length and a premium from Pond's. 7x4.5" and VG-EX. Fabulous full-color drawings on each page.